|
The first edition of the Encyclopedia of Spectroscopy and Spectrometry, published as a print version in 1999, comprised around 300 articles written by experts in their fields and covered as comprehensive a range of subjects as we were able to commission at the time. I, and my co-editors John Holmes and George Tranter, endeavored to attract authors who could provide up-to-date explanations of the most important spectroscopic and related techniques along with details of their many fields of application.
Around a decade later, we have completed a major update of this work, which has resulted in a print and online reference with more than 100 new and updated articles. Some of the articles have of course not needed to be changed, particularly those that explain the theory behind the various techniques. However, technology has moved on apace in the last 10 years, and many major advances in spectroscopy and spectrometry have been achieved. In this new edition, we hope that we have captured these.
We are very fortunate to have attracted David Koppenaal from the Pacific Northwest National Laboratory in the USA as a new co-editor. With this new editorial team we have reviewed all of the articles in the first edition and commissioned updates for many of these. We have also tried to commission articles on subjects that were not covered in the first edition, reflecting the fact that there are now many new approaches that did not exist 10 years ago.
The encyclopedia is aimed at a professional scientific readership, and we hope that the articles are useful for experts within a given field, and for those interested to find out more about a subject in which they are perhaps not so expert.
John Lindon, George Tranter, and David Koppenaal
 John Lindon
Imperial College London, UK
John Lindon is a Professor and Senior Research Investigator in the Section of Biomolecular Medicine, part of the Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, UK. He is also a founder Director of, and a Consultant to, Metabometrix Ltd, a company spun out of Imperial College to exploit the commercial possibilities of metabonomics.
He obtained his B.Sc, Ph.D. and D.Sc degrees from Birmingham University UK, was a postdoctoral fellow at Columbia University, New York, USA (1969-1970), then joined the Chemistry Department of Southampton University UK, to use NMR methods to research the properties of liquid crystals and to be responsible for the NMR laboratory. From 1976 to 1995 he was at the Wellcome Research Laboratories (a pharmaceutical company) in the UK, latterly as Head of Spectroscopy, which is now part of GlaxoSmithKline. He then joined Birkbeck College, University of London, and moved to Imperial College London as part of the transfer of the metabonomics team in 1998.
He has co-authored a book on NMR of oriented molecules, another on metabonomics in toxicology and, in 2007, one on metabonomics in general. He is Editor-in-Chief of the Encyclopedia of Spectroscopy and Spectrometry, serves on the editorial boards of a number of journals and has authored many review articles and chapters, plus around 400 research papers.
His achievements include the pioneering of a range of NMR data acquisition and processing methods, the use of nematic liquid crystals and NMR spectroscopy for determing accurate molecular structures in the liquid state, and the application of spectroscopy and other physical chemistry methods in drug design. Developments of NMR-based approaches in biomedical research include the use of directly-coupled HPLC-NMR, application of high resolution magic-angle-spinning NMR to tissue samples, and the use of NMR and other analytical methods coupled with multivariate statistics to study biofluids and tissues, a field now termed metabonomics.
 George Tranter
Chiralabs Ltd., Oxford, UK
George Tranter is a Director of Chiralabs Ltd., a company he co-founded in 2002 specializing in the analysis and investigation of pharmaceuticals and biopharmaceuticals, especially in terms of their chirality, structure, crystallisation and physicochemical behaviour.
He obtained his BSc and PhD at the Chemistry Department of King’s College, University of London, UK (1977-83), then joined the Theoretical Chemistry Department of the University of Oxford, specializing in chiral phenomena and optical spectroscopies. From 1987 he held senior R&D positions in the pharmaceutical industry (the Wellcome Foundation and GlaxoWellcome), before returning to academia in 2000. Until 2006 he led the Biospectroscopy Centre of Imperial College London and subsequently was Senior Research Fellow of the Department of Chemistry, University of Oxford, maintaining strong collaborative links with the pharmaceutical and biotechnology industries throughout.
He is a recognised authority in chirality and the spectroscopic / physicochemical features of drugs and biopharmaceuticals, a co-inventor of the internationally award-winning rational crystallisation screening technology CrystalGEM® and is a named inventor on drug patents. He has published widely in the scientific literature, is an editor of the Encyclopedia of Spectroscopy and Spectrometry, has been a member of scientific journal editorial boards and appeared on radio and television programmes in the UK and abroad. He is also a member of various scientific advisory panels, has been a Visiting Fellow of the National Physical Laboratory (UK), and is a key partner in collaborations that bring together the biopharmaceutical industry, academia and governmental institutions to investigate and validate biopharmaceutical structure and function. He is a Fellow of the Royal Society of Chemistry (FRSC), a Chartered Chemist (CChem), and a European Chartered Scientist (CSi).
His particular interests are in the rational discovery of new therapeutics, with a passion for the role chirality plays in nature, from the molecular level through to macroscopic structures and beyond. Research and development activities also include the generation of novel technologies to help rationalise poorly understood phenomena. He is also an enthusiastic underwater spectroscopist-photographer studying the unusual spectroscopic characteristics of marine creatures.
David Koppenaal
Pacific Northwest National Laboratory, Richland, WA, USA
Dr. Koppenaal (PhD, University of Missouri Columbia) manages the Biological Separations & Mass Spectrometry group within the Biological Sciences Division of the Fundamental & Computational Sciences Directorate at Pacific Northwest National Laboratory. He manages 65 staff members in the development of high-resolution separations and mass spectrometry and their applications in biological research. The current research emphasis is in the area of proteomics - the study of the entire complement of proteins expressed in a cell under a specific set of conditions at a specific time.
Dr. Koppenaal served as interim Chief Research Officer (CRO) for PNNL from June 2006 through September 2007. From 2003-2006, he managed the Macromolecular Structure and Dynamics group within the Biological Sciences Division. He managed this same group while Associate Director of the W.R. Wiley Environmental Molecular Sciences Laboratory from 1998-2003. In these roles, Dr. Koppenaal oversaw the development, installation, and commissioning of the world's first wide-bore 900 MHz NMR spectrometry system (at that time the highest field NMR in the world).
Dr. Koppenaal's recent research includes the development of new types of mass spectrometry instrumentation and MS detectors based on ion-sensitive arrays (in collaboration with colleagues at the University of Arizona and Indiana University). This research may well provide the basis for a truly simultaneous, "all-the-signal, all-the-time" detector for elemental mass spectrometry, and has recently been highlighted in an Analytical Chemistry 'A' page review article. Another recent interest has taken Dr. Koppenaal into the field of metallomics. He helped introduce the elemental analysis community to this emerging new field and is currently active in the development of new high-resolution instrumentation and methods for the characterization of the metallome.
A former American Chemical Society Analytical Chemistry Division Chair, he is a Fellow of both the American Association for the Advancement of Science and the Royal Society of Chemistry (UK). |
|
